2-Decarboxy-2-hydroxymethyl-PGF1 α analogs

ABSTRACT

This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

The present application is a divisional application of Ser. No. 647,369 filed Jan. 8, 1976, now issued as U.S. Pat. No. 4,032,576 on June 28, 1977.

The present invention relates to prostaglandin analogs, for which the essential material constituting disclosure therefor is incorporated by reference here from Ser. No. 647,369, filed Jan. 8, 1976, now issued as No. 4,032,576. 

We claim:
 1. A prostaglandin analog of the formula ##STR1## wherein M₁ is ##STR2## wherein R₅ is hydrogen or methyl; WHEREIN G IS ONE, 2, OR 3; ANDWherein m is one to 5, inclusive.
 2. A compound according to claim 1, wherein m is one or
 2. 3. A compound according to claim 1, wherein m is 4 or
 5. 4. A compound according to claim 1, wherein m is
 3. 5. A compound according to claim 4, wherein g is one.
 6. A compound according to claim 5, wherein R₅ is hydrogen.
 7. 2-Decarboxy-2-hydroxymethyl-16,16-difluoro-PGF₁ α. 